A biomarker of cognition in Multiple Sclerosis (MS) that is independent from the response of people with MS (PwMS) to test questions would provide a more holistic assessment of cognitive decline. One suggested method involves event-related potentials …
Vigilance is the ability to quickly identify and respond to unpredictable stimuli over an extended period. It is an important part of activities such as driving, flying and radar monitoring, and it is affected by sleep loss. We investigated the …
Resting-state electroencephalography (RSEEG) is a method under consideration as a potential biomarker that could support early and accurate diagnosis of Parkinson’s disease (PD). RSEEG data is often contaminated by signals arising from other …
Current tests of disease status in Parkinson's disease suffer from high variability, limiting their ability to determine disease severity and prognosis. Event-related potentials, in conjunction with machine learning, may provide a more objective …
Our lab collects EEG data to answer questions about how the brain processes faces, about how sleep affects brains, and how the brains of people with Parkinson's disease and Multiple Sclerosis are affected.
Sleep restriction affects attention in different ways. Performance on an attentional blink task was unaffected by sleep restriction in two studies, but performance on a vigilance task was affected in both. In the second study, we looked at resting state EEG and found alpha was reduced after sleep restriction, which may have balanced out performance on the attentional blink task.
**Background:** Huntington's disease (HD) causes progressive atrophy to the striatum, a critical node in frontostriatal circuitry. Maintenance of motor function is dependent on functional connectivity of these premotor, motor, and dorsolateral …
**Background** Huntington's disease (HD) causes progressive motor dysfunction through characteristic atrophy. Changes to neural structure begin in premanifest stages yet individuals are able to maintain a high degree of function, suggesting …
## Background Huntington's Disease causes progressive motor dysfunction through atrophic disruption to the frontal cortical motor circuitry and basal ganglia regions. Symptom onset typically begins at age 40; subsequent neurodegeneration is …